Methylphenidate effects on neural activity during response inhibition in healthy humans.

  title={Methylphenidate effects on neural activity during response inhibition in healthy humans.},
  author={Anna Carolina Pavelec Costa and Michael Riedel and Oliver Pogarell and Frank Menzel-Zelnitschek and Markus M. Schwarz and Maximilian Reiser and Hans-J{\"u}rgen M{\"o}ller and Katya Rubia and Thomas Meindl and Ulrich Ettinger},
  journal={Cerebral cortex},
  volume={23 5},
Methylphenidate (MPH) is a catecholamine transporter blocker, with dopamine agonistic effects in the basal ganglia. Response inhibition, error detection, and its mediating frontostriatal brain activation are improved by MPH in patients with attention-deficit/hyperactivity disorder. However, little is known about the effects of MPH on response inhibition and error processing or its underlying brain function in healthy individuals. Therefore, this study employed functional magnetic resonance… CONTINUE READING
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