Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD).

@article{Vles2003MethylphenidateDT,
  title={Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD).},
  author={Johan Sh Vles and Frans J. M. Feron and Jos Gm Hendriksen and Jelle Jolles and Marinus J. P. G. van Kroonenburgh and Wim E J Weber},
  journal={Neuropediatrics},
  year={2003},
  volume={34 2},
  pages={77-80}
}
Adults suffering from Attention Deficit Hyperactivity Disorder (ADHD) are known to have disturbed central dopaminergic transmission. With Single Photon Emission Computed Tomography (SPECT) we studied brain dopamine transporter and receptor activity in six boys with ADHD. Three months after initiation of treatment with methylphenidate we found a down-regulation of the post-synaptic dopamine receptor with a maximum of 20 % and a down-regulation of the dopamine transporter with a maximum of 74.7… CONTINUE READING

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