Methylphenidate bioavailability from two extended-release formulations.

  title={Methylphenidate bioavailability from two extended-release formulations.},
  author={Mario A. Gonz{\'a}lez and Helen S. Pentikis and N Anderl and Michael F Benedict and Heleen H Decory and Sharon J Hirshey Dirksen and Simon J. Hatch},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={40 4},
OBJECTIVE The objective of these studies was to compare the rate and extent of absorption of d,l-threo-methylphenidate (MPH) from two extended-release products--a capsule formulation containing coated beads and an OROS tablet formulation--in healthy male and female subjects under fasted conditions. MATERIALS Metadate CD (methylphenidate HCl, USP) Extended-Release Capsules and Concerta (methylphenidate hydrochloride) Extended-Release Tablets. METHODS Two studies were conducted: (1) A single… CONTINUE READING
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Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate.

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