Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity

@article{Williard2007MethylphenidateAI,
  title={Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity},
  author={Robin L Williard and Lawrence D. Middaugh and Hao-Jie Zhu and Kennerly Sexton Patrick},
  journal={Behavioural Pharmacology},
  year={2007},
  volume={18},
  pages={39-51}
}
Ethylphenidate is formed by metabolic transesterification of methylphenidate and ethanol. Study objectives were to (a) establish that ethylphenidate is formed in C57BL/6 (B6) mice; (b) compare the stimulatory effects of ethylphenidate and methylphenidate enantiomers; (c) determine methylphenidate and ethylphenidate plasma and brain distribution and (d) establish in-vitro effects of methylphenidate and ethylphenidate on monoamine transporter systems. Experimental results were that: (a… 

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  • R. Dinis-Oliveira
  • Biology, Chemistry
    European Journal of Drug Metabolism and Pharmacokinetics
  • 2016
TLDR
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