Methylphenidate and cocaine: A placebo-controlled drug interaction study

  title={Methylphenidate and cocaine: A placebo-controlled drug interaction study},
  author={Theresa M. Winhusen and Eugene Somoza and Bonita M Singal and Judy M. Harrer and Paul Horn},
  journal={Pharmacology Biochemistry and Behavior},
Up to thirty percent of cocaine addicted individuals may meet diagnostic criteria for Attention-Deficit/Hyperactivity Disorder (ADHD). Methylphenidate (MPH) is a highly effective and commonly used treatment for ADHD but, like cocaine, is a cardiovascular and central nervous system stimulant with the potential to cause toxicity at high doses. The present study was undertaken to investigate the likelihood of a toxic reaction in individuals who use cocaine while concurrently taking MPH. Seven non… CONTINUE READING


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