Methylphenidate and atomoxetine normalise fronto-parietal underactivation during sustained attention in ADHD adolescents

  title={Methylphenidate and atomoxetine normalise fronto-parietal underactivation during sustained attention in ADHD adolescents},
  author={Olivia S. Kowalczyk and A Cubillo and Anna B. Smith and Nadia Barrett and Vincent Giampietro and Michael J. Brammer and Andrew Simmons and Katya Rubia},
  journal={European Neuropsychopharmacology},

Methylphenidate normalizes aberrant beta oscillations and reduces alpha power during retention in children with ADHD

It is shown that methylphenidate restores aberrant patterns of beta desynchronization and reduces alpha power during retention in the ADHD group, concomitant to an improvement in behavioural performance.

Dorsal‐to‐ventral imbalance in the superior longitudinal fasciculus mediates methylphenidate’s effect on beta oscillations in ADHD

Based on MPH’s modulatory effects on striatal dopamine levels, data suggest that the behavioral deficits and aberrant oscillatory modulations observed in ADHD depend on a structural connectivity imbalance within the SLF, caused by a diffusivity gradient in favor of temporal rather than parietal, fiber tracts.

A Retrospective Comparative Study in Patients With Cocaine Use Disorder Comorbid With Attention Deficit Hyperactivity Disorder Undergoing an rTMS Protocol Treatment

This is the first study comparing the demographic characterization and rTMS clinical improvements of patients with a dual diagnosis of ADHD and CocUD against CocUD-only patients and both groups significantly improved over time regarding cocaine use, craving, and other negative affect symptoms.

Correlation between brain function and ADHD symptom changes in children with ADHD following a few-foods diet: an open-label intervention trial

Evidence is provided for a neurocognitive mechanism underlying the efficacy of a few-foods diet in children with ADHD and a correlation between ADHD symptom decrease and increased precuneus activation is revealed.

Pharmacological manipulations of physiological arousal and sleep-like slow waves modulate sustained attention

Results suggest that a decrease in arousal can lead to local sleep intrusions during wakefulness which could be mechanistically linked to impulsivity and sluggishness.

Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[11C]methylreboxetine positron emission tomography study

The findings demonstrate the pathophysiological involvement of NET availability in adult ADHD and find a significant main effect group in fronto-parietal-thalamic-cerebellar regions.



Methylphenidate Normalizes Fronto-Striatal Underactivation During Interference Inhibition in Medication-Naïve Boys with Attention-Deficit Hyperactivity Disorder

Functional magnetic resonance imaging was used to investigate the effects of a single dose of MPH on brain activation during interference inhibition in medication-naïve ADHD boys, and MPH appears to have a region-specific upregulation effect on fronto-striatal activation.

The effects of methylphenidate on neural systems of attention in attention deficit hyperactivity disorder.

The results suggest that ADHD is associated with abnormal processing in attentional networks, with specific dysfunction in striatal circuitry, and methylphenidate may act to normalize activity within this network.

Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task.

Methylphenidate OROS increased daMCC activation during the MSIT and may act, in part, by normalizing daMcc hypofunction in ADHD.

Shared and Drug-Specific Effects of Atomoxetine and Methylphenidate on Inhibitory Brain Dysfunction in Medication-Naive ADHD Boys

The findings show shared and drug-specific effects of MPX and ATX on performance and brain activation during inhibitory control in ADHD patients with superior upregulation and normalization effects ofMPX.

Neural correlates of atomoxetine improving inhibitory control and visual processing in Drug‐naïve adults with attention‐deficit/hyperactivity disorder

Treatment with atomoxetine may improve inhibitory control to suppress interference and may enhance the visual processing to process numbers and the anterior cingulate cortex might play an important role as a biological marker for the treatment effectiveness of atomxetine.