Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1

@article{Sun2004MethylphenidateIS,
  title={Methylphenidate Is Stereoselectively Hydrolyzed by Human Carboxylesterase CES1A1},
  author={Zejin Sun and Daryl J. Murry and Sonal P. Sanghani and Wilhelmina I. Davis and Natalia Y. Kedishvili and Qing Zou and Thomas D. Hurley and William F. Bosron},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={310},
  pages={469 - 476}
}
Methylphenidate is an important stimulant prescribed to treat attention-deficit hyperactivity disorder. It has two chiral centers, but most current commercial formulations consist of the racemic mixture of the threo pair of methylphenidate isomers (d-, l-threo-methylphenidate). The d-isomer is the pharmacologically active component. Numerous studies reported that oral administration of the methylphenidate racemate undergoes first-pass, stereoselective clearance in humans with l-methylphenidate… Expand
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