Methylphenidate-Induced Psychosis in Adult Attention-Deficit/Hyperactivity Disorder: Report of 3 New Cases and Review of the Literature

@article{Kraemer2010MethylphenidateInducedPI,
  title={Methylphenidate-Induced Psychosis in Adult Attention-Deficit/Hyperactivity Disorder: Report of 3 New Cases and Review of the Literature},
  author={M Kraemer and Jennifer Uekermann and Jens Wiltfang and Bernhard Kis},
  journal={Clinical Neuropharmacology},
  year={2010},
  volume={33},
  pages={204-206}
}
Objective:We present 3 new cases of psychotic symptoms in patients with adult attention-deficit/hyperactivity disorder while regularly treated with a stimulant therapy with methylphenidate. Methods:Existing literature about this theme is reviewed, and potential mechanisms are discussed. Results and Conclusions:Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a… 
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56 Citations
Highly Influential Citations
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19
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56 Citations

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A case of 11 years old boy with diagnosis of ADHD and mild intellectual disability, who was treated with methylphenidate and later developed acute psychosis is described.
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Two cases were reported who diagnosed with ADHD, and shortly after the beginning of the long-acting metylphenidate treatment psychotic symptoms has emerged, and it was discussed the treatment process of the psychotic symptoms.
Psychosis in a cocaine-dependent patient with ADHD during treatment with methylphenidate.
Reintroduction of stimulant treatment for patients with ADHD, after stimulant-related psychosis
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Three additional cases where rechallenging with stimulant medication did not result in reappearance of psychotic symptoms are reported, and possible risk factors for developing such side effects and hypothesized mechanisms are discussed.
Methylphenidate-Induced Psychotic Symptoms in 65-Year-Old Female with ADHD
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This case presents psychotic manifestations due to methylphenidate in a 65-year-old female who was taking this medication for ADHD who thought that they were sleeping pills and was discontinued which resulted in improvement of her psychosis.
Methylphenidate for psychosis and aggression in a patient comorbid with ADHD - A case report.
TLDR
While caring for a patient with comorbidity of ADHS and psychosis the authors were not able to find guidelines or treatment recommendations issued by a major society concerning state of the art treatment of such a case.
An update on the safety of psychostimulants for the treatment of attention-deficit/hyperactivity disorder
TLDR
Although methylphenidate has a well-established evidence base for treating ADHD, its long-term benefits are unclear and much less is known about longer-term efficacy and safety of these drugs.
Aripiprazole Treatment in a Patient with Schizophrenia and Severe Antipsychotic-Induced Parkinsonism Following Long-Term use of Methylphenidate: A Case Report
  • B. Lee
  • Psychology, Medicine
  • 2016
TLDR
The present case report cautiously suggests the possible value of aripiprazole's stabilizing qualities as a treatment for attention-deficit/hyperactivity disorder.
Does amantadine induce acute psychosis? A case report and literature review
TLDR
Clinicians should be sensitive to the acute psychotic complications induced by an interaction between amantadine and acetaminophen.
Detecting and treating adult attention deficit hyperactivity disorder in a patient with schizophrenia
TLDR
It is indicated that atomoxetine may be effective in treating symptoms of ADHD in patients with schizophrenia, without increasing psychotic symptoms.
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