Methylphenidate-Induced Psychosis in Adult Attention-Deficit/Hyperactivity Disorder: Report of 3 New Cases and Review of the Literature

@article{Kraemer2010MethylphenidateInducedPI,
  title={Methylphenidate-Induced Psychosis in Adult Attention-Deficit/Hyperactivity Disorder: Report of 3 New Cases and Review of the Literature},
  author={M Kraemer and Jennifer Uekermann and Jens Wiltfang and Bernhard Kis},
  journal={Clinical Neuropharmacology},
  year={2010},
  volume={33},
  pages={204-206}
}
Objective:We present 3 new cases of psychotic symptoms in patients with adult attention-deficit/hyperactivity disorder while regularly treated with a stimulant therapy with methylphenidate. Methods:Existing literature about this theme is reviewed, and potential mechanisms are discussed. Results and Conclusions:Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a… 
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References

SHOWING 1-10 OF 24 REFERENCES
[Drug-induced psychosis after intake of a modified--release formulation of methylphenidate].
TLDR
It is concluded that the ingestion of an unintended overdose ofmethylphenidate may have caused the boy's psychotic symptoms and that routine therapeutic serum concentrations of methylphenidate have to be correlated to the point of time when the blood was drawn in relation to the intake ofethylphenidate.
Attention-deficit hyperactivity disorder and comorbid psychosis: a review and two clinical presentations.
TLDR
It is suggested that further attention be given to the evaluation, treatment, and eventual classification of a potentially distinct patient group with ADHD and atypical psychotic episodes.
Methylphenidate-induced hallucinosis: case histories and possible mechanisms of action.
TLDR
It is suggested that methylphenidate-induced hallucinosis is more common than has been appreciated and two other hypotheses that may clarify underlying mechanisms of action that produce toxic effects relate to (1) noradrenergic facilitation of transmission of information in the visual pathway, and (2) interactions among brain monoamine systems.
Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder.
  • R. Ross
  • Psychology, Medicine
    The American journal of psychiatry
  • 2006
A boy 6 years 9 months of age was brought by his mother to a child psychiatrist for difficulties with sustained attention, distraction, careless errors, poor listening, difficulty following
Schizophrenia and narcolepsy: A review with a case report
TLDR
The present case report describes a difficult‐to‐treat patient who likely had concurrent schizophrenia and narcolepsy and summarizes the literature related to the treatment of the three types of patients with psychosis associated with narcoLEpsy.
Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues.
  • T. Wilens
  • Psychology, Medicine
    The Psychiatric clinics of North America
  • 2004
A clinical perspective of attention-deficit/hyperactivity disorder into adulthood.
TLDR
A growing literature indicates that ADHD is more persistent than previously thought and has a developmental variability in its presentation, which suggests the importance of short- and long-term management of the disorder.
Methylphenidate‐Induced Hallucinosis: Case Histories and Possible Mechanisms of Action
  • J. G. Young
  • Medicine, Biology
    Journal of developmental and behavioral pediatrics : JDBP
  • 1981
TLDR
It is suggested that methylphenidate-induced hallucinosis is more common than has been appreciated and two other hypotheses that may clarify underlying mechanisms of action that produce toxic effects relate to (1) noradrenergic facilitation of transmission of information in the visual pathway, and (2) interactions among brain monoamine systems.
Folie à deux with methylphenidate psychosis.
  • J. Spensley
  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1972
Two cases of psychosis associated with oral and intravenous abuse of methylphenidate are reported. Most elements of the classic folie a deux are seen in their identical paranoid delusions. The wife
Risks of high-dose stimulants in the treatment of disorders of excessive somnolence: a case-control study.
TLDR
This study demonstrated a significantly higher occurrence of psychosis, substance misuse, and psychiatric hospitalizations in patients using high-dose stimulants compared to those using standard doses.
...
...