Methylphenidate HCl: therapy for attention deficit hyperactivity disorder

@article{Capp2005MethylphenidateHT,
  title={Methylphenidate HCl: therapy for attention deficit hyperactivity disorder},
  author={Philip K Capp and Phillip L. Pearl and Charles Conlon},
  journal={Expert Review of Neurotherapeutics},
  year={2005},
  volume={5},
  pages={325 - 331}
}
Methylphenidate is a first-line therapy for attention deficit hyperactivity disorder, the most prevalent neuropsychiatric disorder of childhood. The compound is a piperidine and the D-threo-isomer is considered the biologically active form. The compound is available in multiple short- and long-acting preparations, having different delivery systems leading to varying kinetics without clear superiority in efficacy or tolerability at the group level. Common adverse effects are insomnia, appetite… 

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References

SHOWING 1-10 OF 61 REFERENCES

Advances in the Pharmacotherapy of Attention‐Deficit‐Hyperactivity Disorder: Focus on Methylphenidate Formulations

The psychostimulant dl‐methylphenidate (MPH) remains the most common drug therapy in child and adolescent psychiatry for the treatment of attention‐deficit‐hyperactivity disorder (ADHD). Evidence of

Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation.

TLDR
Stimulant medication within this therapeutic range, therefore, results in few, generally mild side effects, and Surprisingly, a high frequency of these behavior side effects were reported during the placebo condition.

Use of methylphenidate in a patient with glaucoma and attention-deficit hyperactivity disorder: a clinical dilemma.

TLDR
When used cautiously in conjunction with glaucoma medications and regular ophthalmologic monitoring, methylphenidate and other psychostimulants may be safe in patients with well-controlled, open-angle glau coma.

Side effects of methylphenidate and dexamphetamine in children with attention deficit hyperactivity disorder: a double-blind, crossover trial.

TLDR
Many symptoms commonly attributed to stimulant medication are actually preexisting characteristics of children with ADHD and improve with stimulant treatment.

Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder

Atomoxetine (Strattera™, Eli Lilly & Co.) is a selective noradrenaline reuptake inhibitor that has been studied for use in the treatment of attention-deficit/hyperactivity disorder (ADHD). So far,

Use of Methylphenidate for Attention-Deficit Hyperactivity Disorder in Patients With Epilepsy or Electroencephalographic Abnormalities

TLDR
Methylphenidate is safe and effective in children with ADHD and concomitant active seizures or EEG abnormalities and had a beneficial effect on EEG.

Serum and brain concentrations of methylphenidate: implications for use and abuse

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

TLDR
The findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD.
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