Methylphenidate Enhances the Abuse-Related Behavioral Effects of Nicotine in Rats: Intravenous Self-Administration, Drug Discrimination, and Locomotor Cross-Sensitization

@article{Wooters2008MethylphenidateET,
  title={Methylphenidate Enhances the Abuse-Related Behavioral Effects of Nicotine in Rats: Intravenous Self-Administration, Drug Discrimination, and Locomotor Cross-Sensitization},
  author={Thomas E. Wooters and Nichole M Neugebauer and Craig R Rush and Michael T. Bardo},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1137-1148}
}
Stimulant drugs, including D-amphetamine, cocaine, and methylphenidate, increase cigarette smoking in controlled human laboratory experiments. Although the mechanism(s) underlying this effect are unknown, it is possible that stimulants may enhance directly the abuse-related effects of nicotine. In the present study, we characterized the behavioral pharmacological interactions between methylphenidate and nicotine in the intravenous self-administration, drug discrimination, and locomotor cross… CONTINUE READING

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Preexposure to nicotine alters the subsequent locomotor stimulant effects of bupropion in rats.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco • 2006
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