Methylphenidate : a treatment for Parkinson's disease?

  title={Methylphenidate : a treatment for Parkinson's disease?},
  author={David Devos and Caroline Moreau and Arnaud Delval and Kathy Dujardin and L. Defebvre and R{\'e}gis Bordet},
  journal={CNS drugs},
  volume={27 1},
Parkinson's disease (PD) affects about 1 % of the population over the age of 60 years and is characterized by a combination of rest tremor, bradykinesia, rigidity, postural instability, stooped posture and freezing of gait (FoG). However, the clinical spectrum also spans a wide range of non-motor symptoms, such as depression, apathy, cognitive disorders, sleepiness, fatigue and pain. Given that the loss of dopamine in the striatum is the primary pathochemical hallmark in PD, pharmacological… CONTINUE READING
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