Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial

  title={Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial},
  author={Andreas G. Franke and Patrik Gr{\"a}nsmark and Alexander Agricola and Kai Sch{\"u}hle and Thilo Rommel and Alexandra Sebastian and Harald Ball{\'o} and Stanislav Gorbulev and Christer Gerdes and Bj{\"o}rn Frank and Christian Ruckes and Oliver T{\"u}scher and Klaus Lieb},
  journal={European Neuropsychopharmacology},
Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
The results can inform the use of stimulants for cognitive enhancement purposes as well as direct further research to investigate the effects of stimulant on specific cognitive domains that seem most promising, possibly by using tasks that are more demanding.
Cognitive enhancement: Effects of methylphenidate, modafinil and caffeine on latent memory and resting state functional connectivity in healthy adults
Dopamine's role in attention and memory as well as its ability to modulate FC between large-scale neural networks (e.g. FPN and DMN) as a potential cognitive enhancement mechanism are discussed.
In search of optimal psychoactivation: stimulants as cognitive performance enhancers
The latest and most important research on the relationship between popular stimulants and cognitive enhancement is reviewed, including modafinil, an increasingly popular stimulant that differs from the rest in neurochemical profile and behavioural effects.
The Efficacy of Modafinil as a Cognitive Enhancer
There is only limited potential for modafinil to act as a cognitive enhancer outside sleep-deprived populations, according to the available evidence.
Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects
MDMA induced subjective, emotional, sexual, and endocrine effects that were clearly distinct from those of methylphenidate and modafinil at the doses used.
Is Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?
  • A. Kapur
  • Psychology, Medicine
    CNS Drugs
  • 2020
Methylphenidate appears to produce dose-dependent benefits to individuals with attention-deficit/hyperactivity disorder, but the evidence for benefit in Parkinson’s disease and schizophrenia is inconclusive.
Psychostimulants As Cognitive Enhancers in Adolescents: More Risk than Reward?
It is crucial for the scientific community to thoroughly examine the efficacy and safety of these stimulants in healthy populations across development to avoid perpetuating a perception of these drugs as “safe” when that might not be true for developing brains.
Effects of chess on cognitive functions and learning of schoolchildren: a systematic review
This study aimed to systematically review in the literature how the chess game influences cognition and the learning process in the school population. Method: Were consulted the PubMed, Scopus,


Cognitive enhancing effects of modafinil in healthy volunteers
Data indicate that modafinil selectively improves neuropsychological task performance, suggesting that modAFinil may be of benefit in the treatment of attention deficit hyperactivity disorder.
Effect of modafinil on cognitive functions in alcohol dependent patients: A randomized, placebo-controlled trial
Subgroup analyses revealed that modafinil did improve both working memory and verbal short-term memory in AD patients with a poor working memory ability at baseline, whereas no significant treatment effect of modaf inil was found on these two dependent variables in patients with good working memory skills at baseline.
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil.
Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
In for a Penny, in for a Pound: Methylphenidate Reduces the Inhibitory Effect of High Stakes on Persistent Risky Choice
The findings suggest that elevated catecholamine activity by MPH can disrupt inhibitory influences on persistent risky choice in healthy adults.
Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies.
It is shown that single doses of MPH improve cognitive performance in the healthy population in the domains of working memory and speed of processing, and to a lesser extent may also improve verbal learning and memory and reasoning and problem solving.
Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers
The current data suggest that the cognitive effects of modafinil on performance accuracy and latency are dissociable in terms of their neurochemical mechanisms.
Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol
Evidence supports a hypothesis that stop and go processes are under control of distinct neurochemical mechanisms.