Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.

Abstract

Methylosome protein 50 (MEP50) is a component of methylosome where MEP50 binds protein substrates and activates the oncogenic protein arginine methyl transferase 5 (PRMT5). MEP50 is also a coactivator for androgen receptor (AR) and estrogen receptor (ER), and transforms cells in the presence of androgen or estrogen. To extend the understanding of how MEP50… (More)
DOI: 10.1016/j.cellsig.2014.09.014

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