Methylomics of gene expression in human monocytes.

  title={Methylomics of gene expression in human monocytes.},
  author={Yongmei Liu and Jingzhong Ding and Lindsay M Reynolds and Kurt Lohman and Thomas C Register and Alberto de la Fuente and Timothy D. Howard and Greg A. Hawkins and Wei Cui and Jessica Morris and Shelly G. Smith and Robert G. Barr and Joel D. Kaufman and Gregory L Burke and Wendy S. Post and Steven Shea and Charles E McCall and David M Siscovick and David R. Jacobs and Russell P Tracy and David M. Herrington and Ina Hoeschele},
  journal={Human molecular genetics},
  volume={22 24},
DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of gene expression; however, the extent to which methylation of CpG dinucleotides correlates with gene expression at the genome-wide level is still largely unknown. Using purified primary monocytes from subjects in a large community-based cohort (n = 1264), we characterized methylation (>485 000 CpG sites) and mRNA expression (>48K transcripts) and carried out genome-wide association analyses of 8370… CONTINUE READING