Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.

@article{Yuan2006MethylnaltrexoneAN,
  title={Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.},
  author={Chun-Su Yuan and Robert Joseph Israel},
  journal={Expert opinion on investigational drugs},
  year={2006},
  volume={15 5},
  pages={541-52}
}
Methylnaltrexone is an investigational peripheral opioid receptor antagonist, a quaternary derivative of naltrexone. Methylnaltrexone has greater polarity and lower lipid solubility, thus it does not cross the blood-brain barrier in humans. Methylnaltrexone offers the therapeutic potential to block or reverse the undesired side effects of opioids that are mediated by receptors located in the periphery (e.g., in the gastrointestinal tract), without affecting analgesia or precipitating the opioid… CONTINUE READING
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