Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection.

@article{Schrder1991MethylnaloxoniumDO,
  title={Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection.},
  author={Reinier Schr{\"o}der and Matthew B. Weinger and L Vakassian and George F. Koob},
  journal={Neuroscience letters},
  year={1991},
  volume={121 1-2},
  pages={173-7}
}
The value of intracerebral injections as a means of relating brain structure and function is dependent on the degree of site specificity of the injection. The purpose of this study was to compare the distribution over time of naloxone and its quaternary derivative, methylnaloxonium, after intracerebral microinjection. One microliter of tritiated naloxone (NAL) or methylnaloxonium (MN 10.0 ng, 12.8 nCi for both drugs) was infused directly into the n. raphe pontis. Each animal was then… CONTINUE READING

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