Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices

@article{Gutirrez2018MethylmercuryRS,
  title={Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices},
  author={Javiera Estefany Barrientos Guti{\'e}rrez and Andr{\'e}s Mateo Baraibar and Elisa Albi{\~n}ana and Pilar Garc{\'i}a Velasco and Juan Mart{\'i}nez Sol{\'i}s and Jes{\'u}s Miguel Hern{\'a}ndez-Guijo},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2018},
  volume={470},
  pages={1221-1230}
}
In a previous study, we pointed out that the neurotoxic action evoked by methylmercury (MeHg), a potent environmental pollutant responsible for fatal food poisoning, is associated with alterations of cellular excitability by irreversible blockade of sodium and calcium currents. Here, we investigated the MeHg effects on synaptic transmission and neuronal plasticity using extracellular field recording in CA1 area of rat hippocampal slices. MeHg caused a fast and drastic depression of evoked field… CONTINUE READING
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