Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.

@article{Franco2009MethylmercuryNI,
  title={Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.},
  author={Jeferson Lu{\'i}s Franco and Tha{\'i}s Posser and Peter Dunkley and Phillip W. Dickson and Jac{\'o} Joaquim Mattos and Roberta de Paula Martins and Afonso Celso Dias Bainy and Maria Rita Marques and Alcir Luiz Dafre and Marcelo Farina},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 4},
  pages={449-57}
}
In this study, we investigated the involvement of glutathione peroxidase-GPx in methylmercury (MeHg)-induced toxicity using three models: (a) in mouse brain after treatment with MeHg (40 mg/L in drinking water), (b) in mouse brain mitochondrial-enriched fractions isolated from MeHg-treated animals, and (c) in cultured human neuroblastoma SH-SY5Y cells. First, adult male Swiss mice exposed to MeHg for 21 days showed a significant decrease in GPx activity in the brain and an increase in poly(ADP… CONTINUE READING