Methylmercury measurement in whole blood by isotope-dilution GC-ICPMS with 2 sample preparation methods.

@article{Baxter2007MethylmercuryMI,
  title={Methylmercury measurement in whole blood by isotope-dilution GC-ICPMS with 2 sample preparation methods.},
  author={Douglas C Baxter and Ilia Rodushkin and Emma Engstr{\"o}m and Dennis Klockare and Hans Waara},
  journal={Clinical chemistry},
  year={2007},
  volume={53 1},
  pages={111-6}
}
BACKGROUND Despite its known toxicity, methylmercury is rarely measured directly in clinical studies; instead, conclusions are based on total mercury measurements. We have developed isotope-dilution-based methods for methylmercury-specific analysis of whole blood by coupled gas chromatography-inductively coupled plasma mass spectrometry (GC-ICPMS). METHODS We analyzed animal and human blood samples after alkaline digestion or extraction of methylmercury into dichloromethane and back… CONTINUE READING