Methylmercury induces a spontaneous, transient slow inward chloride current in Purkinje cells of rat cerebellar slices.

@article{Yuan2004MethylmercuryIA,
  title={Methylmercury induces a spontaneous, transient slow inward chloride current in Purkinje cells of rat cerebellar slices.},
  author={Yukun Yuan and William David Atchison},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={313 2},
  pages={
          751-64
        }
}
Methylmercury (MeHg; 10-100 microM) induced a spontaneous, transient, slow inward current in Purkinje cells in rat cerebellar slices. Insensitivity of this current to tetrodotoxin suggests that its generation is not related to presynaptic firing. The present study was designed to attempt to identify the ionic origin of this current. Neither Gd(3+), a nonspecific cation channel blocker, nor tetrakis(2-pyridylmethyl)ethylethylenediamine, which chelates Zn(2+), could prevent this current… CONTINUE READING

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