Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells.

@article{hare1993MethylmercuryII,
  title={Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells.},
  author={malcolm. hare and Kim M McGinnis and William D. Atchison},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={266 3},
  pages={1626-35}
}
To determine if methylmercury (MeHg) increased [Ca++]i in intact neuron-like cells, we initiated studies using fluorescence microscopy of single NG108-15 cells preloaded with fura-2. Whereas at 0.5 microM, MeHg had no effect on the ratio of fura-2 fluorescence at 340/380 nm, at 2 and 5 microM it produced a biphasic increase in this ratio. The initial phase increase was sustained; its time to onset was concentration-dependent whereas its maximum increase was not. This phase likely consists of… CONTINUE READING
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