Methylmercury cytotoxicity in PC12 cells is mediated by primary glutathione depletion independent of excess reactive oxygen species generation.

@article{Gatti2004MethylmercuryCI,
  title={Methylmercury cytotoxicity in PC12 cells is mediated by primary glutathione depletion independent of excess reactive oxygen species generation.},
  author={Rita Gatti and Silvana Belletti and Jacopo Uggeri and Maria Vittoria Vettori and Antonio Mutti and Renato Scandroglio and Guido Orlandini},
  journal={Toxicology},
  year={2004},
  volume={204 2-3},
  pages={175-85}
}
Low doses, chronic exposure to mercurial organic compounds is a worldwide health concern and could be pathogenetically relevant as co-factor in several neurodegenerative diseases. In this in vitro study we wanted to further improve our knowledge on the mechanisms of toxicity of methylmercury hydroxide (MeHgOH) in the unprimed PC12 cell line. Cell viability, mitochondrial function, redox state, and cell morphology were recorded at different time points to sequence the events leading to cell… CONTINUE READING