Methylmercury and H(2)O(2) provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis.

@article{Dar2001MethylmercuryAH,
  title={Methylmercury and H(2)O(2) provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis.},
  author={Elisabetta Dar{\'e} and Wei Li and Boris Zhivotovsky and Xi-ming Yuan and Sandra Ceccatelli},
  journal={Free radical biology & medicine},
  year={2001},
  volume={30 12},
  pages={1347-56}
}
Methylmercury (MeHg) is a neurotoxic agent acting via diverse mechanisms, including oxidative stress. MeHg also induces astrocytic dysfunction, which can contribute to neuronal damage. The cellular effects of MeHg were investigated in human astrocytoma D384 cells, with special reference to the induction of oxidative-stress-related events. Lysosomal rupture was detected after short MeHg-exposure (1 microM, 1 h) in cells maintaining plasma membrane integrity. Disruption of lysosomes was also… CONTINUE READING