Methylmercury alters intrasynaptosomal concentrations of endogenous polyvalent cations.

@article{Denny1993MethylmercuryAI,
  title={Methylmercury alters intrasynaptosomal concentrations of endogenous polyvalent cations.},
  author={M F Denny and malcolm. hare and William D. Atchison},
  journal={Toxicology and applied pharmacology},
  year={1993},
  volume={122 2},
  pages={222-32}
}
The effects of the neurotoxic organomercurial methylmercury (MeHg) on intrasynaptosomal polyvalent cation concentrations were examined using fura-2. In the presence of extracellular Ca2+ (Ca2+e), MeHg caused a concentration-dependent, biphasic elevation in the ratio of fluorescence intensity at the emission wavelength of 505 nm following excitation at 340 and 380 nm (340/380 nm ratio). The first phase was independent of Ca2+e and complete within 5 sec. The second phase was dependent upon Ca2+e… CONTINUE READING

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