Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals.

@article{Masjedi2003MethylisothiazolinonesEI,
  title={Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals.},
  author={Khosro Masjedi and Niklas Ahlborg and Birgitta Gruvberger and Magnus Bruze and A T Karlberg},
  journal={The British journal of dermatology},
  year={2003},
  volume={149 6},
  pages={1172-82}
}
BACKGROUND Delayed-type hypersensitivity reactions to nickel (Ni2+) in humans are associated with increased production of both T helper (Th) 1- and Th2-like cytokines. Cytokine responses to the major group of contact allergens, i.e. organic compounds, have been less extensively studied. We have investigated here the cytokine production induced by a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI), the active ingredients in common preservatives that are capable of… CONTINUE READING

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