Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease.

@article{Tajes2014MethylglyoxalRM,
  title={Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease.},
  author={Marta Tajes and Abel Eraso-Pichot and Fanny Rubio-Moscardo and Biuse Guivernau and M{\'o}nica Bosch-Morat{\'o} and Vict{\`o}ria Valls-Comamala and Francisco J Mu{\~n}oz},
  journal={Neuroscience letters},
  year={2014},
  volume={580},
  pages={78-82}
}
Alzheimer's disease (AD) is characterized by the oxidative stress generated from amyloid β-peptide (Aβ) aggregates. It produces protein nitrotyrosination, after the reaction with nitric oxide to form peroxynitrite, being triosephosphate isomerase (TPI) one of the most affected proteins. TPI is a glycolytic enzyme that catalyzes the interconversion between glyceraldehyde 3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP). Methylglyoxal (MG) is a by-product of TPI activity whose production… CONTINUE READING