Methylglyoxal inhibits the binding step of collagen phagocytosis.

@article{Chong2007MethylglyoxalIT,
  title={Methylglyoxal inhibits the binding step of collagen phagocytosis.},
  author={Sandra A C Chong and Wilson Lee and Pam D Arora and Christian Laschinger and Edmond W K Young and Craig A. Simmons and Morris Frank Manolson and Jaro Sodek and Christopher A McCulloch},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 11},
  pages={
          8510-20
        }
}
Bacterial infection-induced fibrosis affects a wide variety of tissues, including the periodontium, but the mechanisms that dysregulate matrix turnover and mediate fibrosis are not defined. Since collagen turnover by phagocytosis is an important pathway for matrix remodeling, we studied the effect of the bacterial and eukaryotic cell metabolite, methylglyoxal (MGO), on the binding step of phagocytosis by periodontal fibroblasts. Type 1 collagen was treated with various concentrations of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

Similar Papers

Loading similar papers…