Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells.

@article{Fukunaga2005MethylglyoxalIA,
  title={Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells.},
  author={Michiru Fukunaga and Satoshi Miyata and Satomi Higo and Yasuhiro Hamada and Shigemitsu Ueyama and Masato Kasuga},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1043},
  pages={151-7}
}
Although recent studies have suggested the potential involvement of apoptotic cell death in the development of diabetic neuropathy, the precise mechanism remains to be elucidated. On the other hand, it is known that the formation of methylglyoxal (MG), a highly reactive dicarbonyl compound, is accelerated under diabetic conditions through several glucose-related metabolisms including the glycation reaction. We found that MG was capable of inducing apoptosis in peripheral nerve-derived Schwann… CONTINUE READING
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