Methylglyoxal has deleterious effects on thioredoxin in human aortic endothelial cells.

@article{Oba2012MethylglyoxalHD,
  title={Methylglyoxal has deleterious effects on thioredoxin in human aortic endothelial cells.},
  author={Tatsuya Oba and Ryosuke Tatsunami and Keisuke Sato and Kyohei Takahashi and Zhihui Hao and Yoshiko Tampo},
  journal={Environmental toxicology and pharmacology},
  year={2012},
  volume={34 2},
  pages={
          117-126
        }
}
Methylglyoxal (MG), a precursor of advanced glycation end products (AGEs), is elevated in diabetic patient's plasma. Some studies have demonstrated that MG induces oxidative stress and apoptosis. Thioredoxin (Trx) is a cytoprotective protein with anti-oxidative and anti-apoptosis functions. In this study, we examined the effects of MG on Trx in human aortic endothelial cells (HAECs). MG increased oxidized-hydroethidine fluorescence intensity, suggesting intracellular accumulation of reactive… CONTINUE READING

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