Methylglyoxal can modify GAPDH activity and structure.

  title={Methylglyoxal can modify GAPDH activity and structure.},
  author={Hyon Jae Lee and Scott K. Howell and Rebecca J Sanford and Paul J. Beisswenger},
  journal={Annals of the New York Academy of Sciences},
The activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) can play an important role in regulating multiple upstream pathways relating to the development of diabetic complications. GAPDH can be modified by a number of metabolic factors, including oxidative and glycation products. To study the effect of glycation on GAPDH we have measured GAPDH structure and activity after exposure of the enzyme to the potent alpha dicarbonyl sugar methylglyoxal (MG). Rabbit GAPDH was incubated with 10… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…