Methylglyoxal and the polyol pathway

@article{Lindstad1993MethylglyoxalAT,
  title={Methylglyoxal and the polyol pathway},
  author={R. I. Lindstad and J. McKinley-McKee},
  journal={FEBS Letters},
  year={1993},
  volume={330}
}
  • R. I. Lindstad, J. McKinley-McKee
  • Published 1993
  • Chemistry, Medicine
  • FEBS Letters
  • Methylglyoxal, 1,2‐propanediol and glycerol are shown to be substrates for sheep liver sorbitol dehydrogenase. With 1,2‐propanediol the enzymecatalyzed reaction occurs specifically with the R(−)‐enantiomer. The maximum velocities and the specificity constants obtained for the three‐carbon substrates are considerably lower than those reported previously for sorbitol, and suggest that rate‐determination is imposed by catalytic steps other than the enzyme‐coenzyme product dissociation. The present… CONTINUE READING
    17 Citations
    Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides.
    • 5
    Inhibition and activation studies on sheep liver sorbitol dehydrogenase.
    • 21
    The non-oxidative degradation of ascorbic acid at physiological conditions.
    • 131
    • PDF
    Reversible inhibition of sheep liver sorbitol dehydrogenase by thiol compounds.
    • 14
    Biosynthesis and Degradation
    Protein Cross-linking by the Maillard Reaction
    • 258
    • PDF
    Polyol pathway and diabetic peripheral neuropathy.
    • P. Oates
    • Medicine
    • International review of neurobiology
    • 2002
    • 249

    References

    SHOWING 1-10 OF 33 REFERENCES
    PARTIAL PURIFICATION AND CHARACTERIZATION OF SORBITOL DEHYDROGENASE FROM RAT BRAIN 1
    • 12
    Novel substrates and inhibitors of human liver sorbitol dehydrogenase.
    • W. Maret
    • Chemistry, Medicine
    • Advances in experimental medicine and biology
    • 1991
    • 11
    Purification and characterization of human liver sorbitol dehydrogenase.
    • 62
    Metabolism of 2-oxoaldehydes in yeasts
    • 31
    Enzyme relationships in a sorbitol pathway that bypasses glycolysis and pentose phosphates in glucose metabolism.
    • J. Jeffery, H. Jörnvall
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1983
    • 110
    • PDF
    The kinetic mechanism of sheep liver sorbitol dehydrogenase.
    • 35