Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells

  title={Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells},
  author={Fernanda Hansen and Daniela Fraga de Souza and Simone da Luz Silveira and Ana L{\'u}cia Hoefel and J{\'u}lia Bijoldo Fontoura and Ana Carolina Tramontina and Larissa Daniele Bobermin and Marina Concli Leite and Marcos Luiz Santos Perry and Carlos Alberto Saraiva Gonçalves},
  journal={Metabolic Brain Disease},
Methylglyoxal is a dicarbonyl compound that is physiologically produced by enzymatic and non-enzymatic reactions. It can lead to cytotoxicity, which is mainly related to Advanced Glycation End Products (AGEs) formation. Methylglyoxal and AGEs are involved in the pathogenesis of Neurodegenerative Diseases (ND) and, in these situations, can cause the impairment of energetic metabolism. Astroglial cells play critical roles in brain metabolism and the appropriate functioning of astrocytes is… CONTINUE READING


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