Methylglyoxal Evokes Pain by Stimulating TRPA1

  title={Methylglyoxal Evokes Pain by Stimulating TRPA1},
  author={David A Andersson and Clive Gentry and Emily Light and Nisha Vastani and Julie Vallortigara and Angelika Bierhaus and Thomas Fleming and Stuart Bevan},
  booktitle={PloS one},
Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound methylglyoxal (MG). Here we show that MG stimulates heterologously expressed TRPA1 in CHO cells and natively expressed TRPA1 in MDCK cells and DRG neurons. MG evokes [Ca(2+)]i-responses in TRPA1 expressing DRG neurons but is without effect in neurons… CONTINUE READING
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