Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis

  title={Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis},
  author={Suzan Wetzels and Kristiaan Wouters and Casper G. Schalkwijk and Tim Vanmierlo and Jerome J A Hendriks},
  journal={International Journal of Molecular Sciences},
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The activation of inflammatory cells is crucial for the development of MS and is shown to induce intracellular glycolytic metabolism in pro-inflammatory microglia and macrophages, as well as CNS-resident astrocytes. Advanced glycation endproducts (AGEs) are stable endproducts formed by a reaction of the dicarbonyl compounds methylglyoxal (MGO) and glyoxal (GO) with amino acids in proteins, during glycolysis… 

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