Methylenetetrahydrofolate reductase polymorphisms and methotrexate: no association with response to therapy nor with drug-related adverse events in an Italian population of rheumatic patients.

@article{Taraborelli2009MethylenetetrahydrofolateRP,
  title={Methylenetetrahydrofolate reductase polymorphisms and methotrexate: no association with response to therapy nor with drug-related adverse events in an Italian population of rheumatic patients.},
  author={Mara Taraborelli and Laura Andreoli and Silvana Archetti and Michel Ferrari and Roberto Cattaneo and Angela Tincani},
  journal={Clinical and experimental rheumatology},
  year={2009},
  volume={27 3},
  pages={499-502}
}
OBJECTIVE MTHFR is an enzyme involved in the folate pathway. It has been suggested that common polymorphisms in its gene (C677T and A1298C) could be related to different methotrexate (MTX) response and toxicity in rheumatoid arthritis (RA) patients. Agreement has not been found yet and there is no data on rheumatic Italian patients. The aim of this study is… CONTINUE READING