Methylenetetrahydrofolate reductase polymorphisms C677T and risk of autism in the Chinese Han population.

@article{Guo2012MethylenetetrahydrofolateRP,
  title={Methylenetetrahydrofolate reductase polymorphisms C677T and risk of autism in the Chinese Han population.},
  author={Tianyou Guo and Hong Chen and Bing Liu and Wei-dong Ji and Chuang Yang},
  journal={Genetic testing and molecular biomarkers},
  year={2012},
  volume={16 8},
  pages={968-73}
}
Causes of autism are still unknown. Some studies have shown that autism might be associated with metabolic abnormalities in the folate/homocysteine pathway, which is involved in DNA methylation, thus altering gene expression. The association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms and the risk of autism is still controversial and ambiguous. The purpose of this study was to examine the effect of the MTHFR C677T polymorphism on the autism risk in the… CONTINUE READING
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