Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population.

@article{Tong2010MethylenetetrahydrofolateRP,
  title={Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population.},
  author={N. A. N. Tong and Yongjun Fang and Jie Li and Meilin Wang and Qin Lu and Shizhi Wang and Yuanyuan Tian and Liucheng Rong and Jielin Sun and Jianfeng Xu and Zhengdong Zhang},
  journal={Cancer science},
  year={2010},
  volume={101 3},
  pages={782-6}
}
Methylenetetrahydrofolate reductase (MTHFR), involved in DNA methylation and nucleotide synthesis, is thought to be associated with a decreased risk of adult and childhood acute lymphoblastic leukemia (ALL). Accumulating evidence has indicated that two common genetic variants, C677T and A1298C, are associated with cancer risk. We hypothesized that these two variants were associated with childhood ALL susceptibility and influence serum MTHFR levels. We genotyped these two polymorphisms and… CONTINUE READING

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References

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Showing 1-10 of 45 references

Cancer statistics , 2008

  • R Siegel
  • CA Cancer J Clin
  • 2008

polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia

  • TL Dunwell, LB Hesson, T Pavlova
  • J Egypt Natl Canc Inst
  • 2007

reduction applied to a large prospective investigation on gene-gene and geneenvironment interactions

  • R Aplenc, J Thompson, P Han
  • Carcinogenesis
  • 2007

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