Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

  title={Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.},
  author={Jason J Ma and Mier J Stampfer and Edward L. Giovannucci and Carmen Artigas and David J. Hunter and Charles S. Fuchs and Walter C Willett and Jacob S Selhub and Charles H. Hennekens and Ramona Rozen},
  journal={Cancer research},
  volume={57 6},
Folate derivatives are important in experimental colorectal carcinogenesis; low folate intake, particularly with substantial alcohol intake, is associated with increased risk. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate necessary for methionine synthesis. A common mutation (677C-->T) in MTHFR reduces enzyme… CONTINUE READING
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