Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion.

Abstract

STUDY QUESTION Is the methylation status of the methylenetetrahydrofolate reductase (MTHFR) promoter region in semen samples associated with 'recurrent spontaneous abortion' (RSA)? SUMMARY ANSWER MTHFR promoter hypermethylation is more frequent in semen samples from RSA couples than in semen samples from infertile couples with no history of RSA (NRSA) and… (More)
DOI: 10.1093/humrep/des319

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@article{Rotondo2012MethylenetetrahydrofolateRG, title={Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion.}, author={John Charles Rotondo and Sandra Bosi and Ediç{\~a}o Ana L. C. Bazzan and Monica Di Domenico and Monica de Mattei and Rita Selvatici and Alfredo Patella and Roberto Marci and M. Sofia Tognon and Fernanda Martini}, journal={Human reproduction}, year={2012}, volume={27 12}, pages={3632-8} }