Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.

@article{Pickell2009MethylenetetrahydrofolateRD,
  title={Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.},
  author={Laura Pickell and Deqiang Li and Katharine V Brown and Leonie G Mikael and Xiaoling Wang and Qing Wu and Li Luo and Loydie A Jerome-Majewska and Rima Rozen},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2009},
  volume={85 6},
  pages={531-41}
}
BACKGROUND Despite extensive research on mild methylenetetrahydrofolate reductase (MTHFR) deficiency and low dietary folate in different disorders, the association of these metabolic disturbances with a variety of congenital defects and pregnancy complications remains controversial. In this study we investigated the effects of MTHFR and dietary folate deficiency at 10.5 days post coitum (dpc) in our mouse model of mild MTHFR deficiency. METHODS Mthfr +/+ and +/- female mice were fed a control… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…