Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease.

@article{Couturaud2000MethylenetetrahydrofolateRC,
  title={Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease.},
  author={Francis Couturaud and Emmanuel Oger and J. H. Abalain and Evelyne Chenu and Bruno Guias and Herv{\'e} Henri Floch and Bernard Mercier and Dominique Mottier and Christophe Leroyer},
  journal={Respiration; international review of thoracic diseases},
  year={2000},
  volume={67 6},
  pages={657-61}
}
BACKGROUND Many studies have suggested an increased risk of venous thromboembolism (VTE) in patients with mild hyperhomocysteinemia. The C677T mutation in the MTHFR gene has recently been described as a cause of mild hyperhomocysteinemia. OBJECTIVES To investigate the potential of the C677T mutation in the MTHFR gene in its homozygous state as a risk factor for VTE. METHODS Case-control study design. The presence of the mutation was determined in all consecutive patients referred from July… CONTINUE READING