Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.

  title={Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.},
  author={Jacob S. Elkins and S C Johnston and Elad Ziv and D M Kado and Jane A. Cauley and Kristine Yaffe},
  journal={American journal of epidemiology},
  volume={166 6},
Homocysteine may play a causal role in cognitive decline. The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocysteine levels, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective cohort study of older women in four US states. During the years 1986-1998, the authors assessed whether the distribution of MTHFR C677T genotypes was independent of potential confounders and whether persons with… CONTINUE READING

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