Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.

@article{Quinlivan2005MethylenetetrahydrofolateR6,
  title={Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.},
  author={Eoin P. Quinlivan and Steven R. Davis and Karla P Shelnutt and George N. Henderson and Haifa Ghandour and Barry Shane and Jacob Selhub and Lynn B. Bailey and Peter W. Stacpoole and Jesse F. Gregory},
  journal={The Journal of nutrition},
  year={2005},
  volume={135 3},
  pages={
          389-96
        }
}
  • Eoin P. Quinlivan, Steven R. Davis, +7 authors Jesse F. Gregory
  • Published 2005
  • Biology, Medicine
  • The Journal of nutrition
  • The methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism is thought to influence the partitioning of 1-carbon units between methylation and other components of 1-carbon metabolism and to influence the risk and etiology of several major cancers and cardiovascular disease. Our objective was to determine the effect of the MTHFR 677C-->T polymorphism and folate status on the relative rate and extent of in vivo synthesis of DNA precursors. Adequately nourished, healthy women (9 CC, 9 TT… CONTINUE READING

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