Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa.

@article{Bronowicki2008MethylenetetrahydrofolateR6,
  title={Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa.},
  author={J P Bronowicki and Idrissia Abdelmouttaleb and Laurent Peyrin-Biroulet and V{\'e}ronique Venard and Hac{\`e}ne Khiri and Nicod{\`e}me Worou Chabi and Emile Kou Santa Amouzou and H{\'e}l{\`e}ne Barraud and Philippe Halfon and Ambaliou Sanni and M. -A. Bigard and Alain Le Faou and Jean-Louis Gu{\'e}ant},
  journal={Journal of hepatology},
  year={2008},
  volume={48 4},
  pages={532-9}
}
BACKGROUND/AIMS Homocysteine metabolism is linked to DNA methylation, a mechanism potentially involved in the course of hepatitis B virus (HBV) infection. We evaluated the association of determinants of homocysteine metabolism with the outcome of HBV infection. METHODS Four hundred and fifty-five healthy adults from Togo and Benin were tested for HBV serologic markers, HLA DR alleles, folate, vitamin B12, methylenetetrahydrofolate reductase (MTHFR) 677 C-->T, 1298 A-->C and methionine… CONTINUE READING

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Highly Influenced

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