Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.

  title={Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.},
  author={Simon Gilbody and Sarah J. Lewis and Tracy J. Lightfoot},
  journal={American journal of epidemiology},
  volume={165 1},
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. The primary comparison was between homozygote variants and the wild type for MTHFR C677T and A1298C. For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds… 

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Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia.
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The frequency of the common C667 T variant of the enzyme methylenetetrahydrofolate reductase in controls and patients of Chinese descent provided some evidence of increased risk for individuals with the T-containing genotypes.
Methylenetetrahydrofolate reductase variant and schizophrenia/depression.
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Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia and these observations support a causal relation between disturbed homocy steine metabolism and schizophrenia.
The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland
A MTHFR C677T genotype is associated with increased risk of depressive episodes in this homogenous patient population and serum levels of folate, homocysteine and vitamin B12 did not differ significantly between groups.
Association between the methylenetetrahydrofolate reductase 677C→T missense mutation and schizophrenia
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