Methylene dianiline: acute toxicity and effects on biliary function.

  title={Methylene dianiline: acute toxicity and effects on biliary function.},
  author={Mary F. Kanz and Lata Kaphalia and Bhupendra S. Kaphalia and Eleonora Romagnoli and G. A. Shakeel Ansari},
  journal={Toxicology and applied pharmacology},
  volume={117 1},
4,4'-Methylene dianiline (4,4'-diaminodiphenylmethane, DAPM), which is used in the polymer industry, causes hepatobiliary damage in exposed humans. Our objectives were to characterize the acute toxicity of DAPM in liver, particularly on secretion of biliary constituents and on biliary epithelial cell gamma-glutamyl transpeptidase (GGT) activity. Biliary cannulas were positioned in Sprague-Dawley male rats under pentobarbital anesthesia. After 1 hr of control bile collection, each rat was given… CONTINUE READING


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