Methylene blue stimulates 2-deoxyglucose uptake in L929 fibroblast cells.

@article{Louters2006MethyleneBS,
  title={Methylene blue stimulates 2-deoxyglucose uptake in L929 fibroblast cells.},
  author={Larry L. Louters and Samuel G Dyste and Deborah Frieswyk and Aaron Tenharmsel and Tim O Vander Kooy and Lindsey Walters and Teresa Whalen},
  journal={Life sciences},
  year={2006},
  volume={78 6},
  pages={586-91}
}
Methylene blue (MB), a common cell stain, has been shown to inhibit nitric oxide synthase and guanylate cyclase, which has led to the recent use of MB in nitric oxide signaling studies. This study documents the effects of MB on 2-deoxyglucose (2DG) uptake in L929 fibroblast cells where uptake is controlled by a single glucose transporter, GLUT 1. MB significantly activates cytochalasin B-inhibitable glucose transport in a dose dependent fashion within 10 min. A maximal stimulation of up to 800… CONTINUE READING

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