Methylene blue inhibits the antithrombotic effect of nitroglycerin.


OBJECTIVES The aim of this study was to examine whether cyclic guanosine monophosphate (GMP) may be involved in the antithrombotic action of nitroglycerin. BACKGROUND Nitroglycerin has been shown to inhibit platelet function in vitro by stimulating prostacyclin or inhibiting thromboxane A2 production, or both. Nitroglycerin has also been shown to possess… (More)


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@article{Johnstone1993MethyleneBI, title={Methylene blue inhibits the antithrombotic effect of nitroglycerin.}, author={Michael T. Johnstone and Jennifer Y. Lam and Ludovic Lacoste and Johanne Baribeau and Pierre Th{\'e}roux and David D Waters}, journal={Journal of the American College of Cardiology}, year={1993}, volume={21 1}, pages={255-9} }