Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart

  title={Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart},
  author={J. Berthiaume and Chia-Heng Hsiung and Alison B Austin and Sean Mcbrayer and Mikayla M. Depuydt and M. Chandler and M. Miyagi and Mariana G Rosca},
  journal={Molecular and Cellular Biochemistry},
  pages={7 - 24}
  • J. Berthiaume, Chia-Heng Hsiung, +5 authors Mariana G Rosca
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • Diabetic cardiomyopathy is preceded by mitochondrial alterations, and progresses to heart failure. We studied whether treatment with methylene blue (MB), a compound that was reported to serve as an alternate electron carrier within the mitochondrial electron transport chain (ETC), improves mitochondrial metabolism and cardiac function in type 1 diabetes. MB was administered at 10 mg/kg/day to control and diabetic rats. Both echocardiography and hemodynamic studies were performed to assess… CONTINUE READING
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