Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart

@article{Berthiaume2017MethyleneBD,
  title={Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart},
  author={J. Berthiaume and Chia-Heng Hsiung and Alison B Austin and Sean Mcbrayer and Mikayla M. Depuydt and M. Chandler and M. Miyagi and Mariana G Rosca},
  journal={Molecular and Cellular Biochemistry},
  year={2017},
  volume={432},
  pages={7 - 24}
}
  • J. Berthiaume, Chia-Heng Hsiung, +5 authors Mariana G Rosca
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • Diabetic cardiomyopathy is preceded by mitochondrial alterations, and progresses to heart failure. We studied whether treatment with methylene blue (MB), a compound that was reported to serve as an alternate electron carrier within the mitochondrial electron transport chain (ETC), improves mitochondrial metabolism and cardiac function in type 1 diabetes. MB was administered at 10 mg/kg/day to control and diabetic rats. Both echocardiography and hemodynamic studies were performed to assess… CONTINUE READING
    8 Citations
    Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy
    • 30
    • PDF
    Methylene blue alleviates endothelial dysfunction and reduces oxidative stress in aortas from diabetic rats.
    • 3
    Metabolic regulation of endothelial SK channels and human coronary microvascular function.
    • 1

    References

    SHOWING 1-10 OF 66 REFERENCES
    Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart.
    • 52
    • PDF
    Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
    • 303
    • PDF
    SIRT3 deficiency impairs mitochondrial and contractile function in the heart
    • 82
    Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.
    • 254
    • PDF
    Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
    • 486
    • PDF
    Cyclophilin D Modulates Mitochondrial Acetylome
    • 48
    • PDF
    SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    • 764
    • PDF