Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.


Major histocompatibility (MHC) class II molecules are strongly associated with many autoimmune disorders. In type 1 diabetes, the DQ8 molecule is common, confers significant disease risk and is involved in disease pathogenesis. We hypothesized blocking DQ8 antigen presentation would provide therapeutic benefit by preventing recognition of self-peptides by… (More)
DOI: 10.1172/JCI97739

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